From Red Carpets to Longevity: 15 Celebrities Taking NAD+

Introduction: An Old Obsession With a New Molecule

The pursuit of anti-aging is not a modern obsession; it is one of humanity’s oldest quests. What has changed is not the desire to stay younger, but the science, technology, and molecules being investigated to understand whether aging itself can be slowed, modified, or potentially reversed. 

Long before "NAD+" became a wellness buzzword, the idea of reversing age was already written on papyrus. The Edwin Smith Papyrus, an ancient Egyptian medical text, contains a preparation explicitly labeled “a recipe for turning an old man into a youth”, built around bitter-almond extract. The Ebers Papyrus, another major Egyptian medical scroll, along with later Greco-Roman sources, describes elaborate skin and rejuvenation treatments using natron, frankincense, honey, and plant oils that Egyptian physicians and priests associated with preserving youthfulness. Historians of aging research also note that ancient Egyptians used large quantities of garlic, believing it helped extend life. The ingredients were different, but the underlying concept — that aging could be slowed or partly reversed through the right substance — is thousands of years old.

Fast forward to the 2020s, and that same impulse has a new name: NAD+ (nicotinamide adenine dinucleotide), along with its precursors NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside). These molecules power cellular energy production and DNA repair, and levels of NAD+ naturally decline with age — a fact that has turned NAD+ optimization into one of the most talked-about trends in modern longevity science, biohacking, and celebrity wellness culture.

This article maps out who in the public eye has actually gone on record about NAD+, NMN, or NR — separating verified statements from marketing claims, and clearly distinguishing serious researchers from entertainers who've simply tried a clinic treatment. It also flags a few of the biggest names in sports who are not verifiably linked to NAD+, despite the trend's popularity in athletic circles.

NAD+ vs. NMN vs. NR: Know the Difference

• NMN (nicotinamide mononucleotide) is a precursor molecule the body converts into NAD+. It's typically taken as an oral capsule, tablet, or powder.
• NR (nicotinamide riboside) is a different precursor that also raises NAD+, also usually taken orally.
• NAD+ is the active coenzyme itself. It can be taken directly, most commonly via IV infusion or intramuscular injection, since oral NAD+ has poor bioavailability.

Clinics offering "NAD+ therapy" to celebrities are almost always administering the IV/infusion form, while biohackers and researchers who talk about a daily "stack" are usually referring to oral NMN or NR capsules.

The Celebrity Database - NAD+ Supplement

Jennifer Aniston 

Jennifer Aniston doesn’t chase youth — she invests in longevity.

Jennifer Aniston has openly incorporated NAD+ into her wellness routine, reportedly receiving weekly NAD+ IV treatments. In her 2023 Wall Street Journal interview, she described the therapy as “the future,” helping push NAD+ further into the mainstream celebrity wellness conversation.

Hailey Bieber and Kendall Jenner

Hailey Bieber and Kendall Jenner helped bring NAD+ into the mainstream wellness conversation when they were shown receiving NAD+ IV infusions together on an episode of The Kardashians. During the 2022 episode, Bieber famously told Jenner, “I’m going to NAD for the rest of my life, and I’m never going to age.” 

Joe Rogan

In a 2020 conversation with Joe Schilling, Rogan talked about getting NAD IV therapy, saying that it was supposed to help keep the body functioning “younger,” and that he felt very good after it. He also described NAD as something that helps the body convert nutrients into energy.

Gwyneth Paltrow

Gwyneth Paltrow has openly embraced NAD+ as part of her wellness and longevity routine, discussing NAD+ IV drips and an NAD+ pen she uses when she wants an extra boost. She has described NAD+ as an important compound for cellular metabolism and repair. Her wellness brand, Goop, has also incorporated NMN, an NAD+ precursor, into its skincare products, highlighting the growing connection between NAD+, longevity, and healthy aging. While Paltrow’s experience reflects the rising popularity of NAD+ among wellness enthusiasts, ongoing research is still exploring its potential benefits.

Justin Bieber

Justin Bieber has also publicly shared his experience with NAD+ IV therapy, including showing himself receiving NAD+ infusions in his Seasons documentary. Reports describe him using the therapy as part of his wellness and recovery routine, with Bieber saying NAD+ helped him with energy and recovery. His use of NAD+ has helped bring the therapy further into mainstream celebrity wellness culture, although his personal experience should not be considered clinical evidence of its effectiveness.

Michelle Pfeiffer

Michelle Pfeiffer has been associated with NAD+ therapy as part of the broader celebrity longevity movement, but she approaches aging from a more balanced, “pro-aging” perspective rather than presenting NAD+ as a way to stop aging. Reports have linked her to NAD+ wellness treatments, while Pfeiffer herself emphasizes the fundamentals of healthy aging—good nutrition, regular exercise, sleep, and overall well-being. 

Shannon Sharpe

NFL Hall of Famer Shannon Sharpe has become one of the prominent athletes associated with NAD+ and healthy-aging supplements. He has promoted NAD+ precursor supplementation, particularly through Tru Niagen, and has appeared in campaigns discussing NAD+ levels, energy, recovery, and aging. His involvement highlights how NAD+ has moved beyond the biohacking community into the world of professional sports and athletic performance.

Erin Andrews

NFL sportscaster Erin Andrews has openly embraced NAD+ as part of her wellness routine. She has described herself as being on a “whole NAD journey” and said she had been receiving NAD+ treatments for about six months, noting that athletes use them for areas such as inflammation, immune support, and cellular health. She later shared that she receives an NAD+ IV approximately every six weeks and is particularly interested in its potential for energy and cognitive benefits.

Kathy Hilton

Kathy Hilton has openly embraced NAD+ as part of her wellness and beauty routine. She has said she takes NAD+ capsules daily and receives Niagen+ IV treatments weekly or every 7–10 days to support her NAD+ levels. Hilton has described the treatment as a “game changer,” associating it with more energy, better sleep, and healthier hair and nails. She has even hosted wellness parties where guests could receive the same NAD-related IV treatment she uses.

Kim Kardashian

Kim Kardashian has spoken publicly about NMN, the NAD+ precursor, as part of an extensive daily supplement stack. On the May 2026 episode of Amy Poehler's Good Hang podcast, Kardashian said she takes "probably 35 supplements a day," splitting them into three doses to make them more manageable. Reporting on the interview notes that fish oil, creatine, cognitive nootropics, and NMN are recurring names in her stack, and that she has taken NMN daily for over a year. Kardashian has also said she wishes she could get a daily IV infusion on her way to work, underscoring her interest in the convenience of NAD+-related treatments even if she hasn't detailed using IV NAD+ specifically. Her involvement in the space extends beyond personal use: in October 2025 she was named as one of the backers in a $60 million funding round for Bryan Johnson's longevity company Blueprint, and she has been linked socially to figures like Johnson and Andrew Huberman through shared longevity-focused dinners.

David Sinclair

Harvard geneticist David Sinclair is one of the most prominent researchers associated with NAD+ and longevity science. His research has explored how NAD+ levels interact with sirtuins, cellular energy, and the biology of aging, and his lab helped establish an important role for NAD+ biosynthesis in aging research.

Bryan Johnson

Longevity entrepreneur Bryan Johnson has made NAD+ optimization a major part of his Blueprint protocol. His regimen has included NAD+ precursors such as NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide), which the body can use to produce NAD+. His current Blueprint Essential Capsules contain NR specifically to support NAD+ levels, while his earlier protocols are documented using either NR or NMN.

Ash K Holm

Celebrity makeup artist Ash K Holm, known for creating looks for stars including Ariana Grande, Kim Kardashian, and Camila Cabello, has openly incorporated NAD+ infusions into her wellness routine. She has said she receives an NAD+ treatment about once a month and sometimes gets an NAD+ drip or shot the day before demanding music-video shoots. Holm credits the treatment with helping her maintain focus and fine motor skills during long workdays. She is also a co-founder of Dripology, a Santa Monica wellness clinic offering IV treatments.

Andrew Huberman

Stanford neuroscientist and Huberman Lab podcast host Andrew Huberman has discussed NAD+ and its precursors extensively, both in a dedicated AMA episode on longevity supplements and in a lengthy 2024 conversation with physician-researcher Dr. Peter Attia on the NAD pathway. Huberman has said he takes NR (nicotinamide riboside) and NMN daily, reporting sustained physical and mental energy and a noticeable dip when he stopped. He has also mentioned occasional NAD+ infusions, while being careful to note that current data doesn't support lifespan-extension claims for NAD+ or its precursors — framing his own use as an energy tool rather than an anti-aging guarantee. His comparatively cautious, evidence-first take stands apart from the more enthusiastic celebrity accounts elsewhere on this list.

Celebrity → What Exactly Did They Take?

Who Started First? A Rough Timeline

1. David Sinclair — the earliest and most research-grounded public figure in this space, discussing NMN publicly around the release of his 2019 book Lifespan, well before it became a mainstream celebrity trend.
2. Hailey Bieber and Kendall Jenner — among the earliest non-scientist public figures reported to use NAD+ IV therapy, dating back to 2022.
3. Bryan Johnson — began his highly public Blueprint protocol, including NMN/NR use, around 2021–2023, later publishing extensive biomarker data.
4. Joe Rogan, Gwyneth Paltrow, Jennifer Aniston, Kathy Hilton, Erin Andrews, Shannon Sharpe — folded into mainstream wellness press coverage mainly from 2024 onward, as NAD+ clinics expanded and media coverage of the trend accelerated.

Who Should Not Take NAD+ Supplements Without Medical Advice?

NAD+, NMN, and NR are marketed as wellness products, but they are not risk-free for everyone. People in the following situations should talk to a doctor before starting:

• Pregnant or breastfeeding individuals
• Anyone with a history of cancer, since NAD+ pathways are also involved in cell proliferation and this remains an active area of research
• People on blood thinners or other prescription medications, due to potential interactions
• Anyone with kidney or liver conditions
• People considering IV infusion specifically, given the risks associated with any infusion (infection at the site, vein irritation, allergic-type reactions)
• Anyone currently being treated for a chronic illness who hasn't discussed supplement use with their treating physician

NAD+ Celebrity Fact-Checking Table

Natural Ways to Support NAD+ Levels

Supplementation isn't the only lever. Several everyday habits are linked to healthier NAD+ metabolism:

• Exercise: Regular aerobic and resistance training is associated with better NAD+ metabolism and mitochondrial function.
• Sleep: Consistent, adequate sleep supports the circadian regulation of NAD+ production.
• Balanced diet: Foods naturally containing NAD+ precursors — including dairy, mushrooms, edamame, broccoli, and avocado — provide a dietary source of support.
• Vitamin B3 sources: Niacin-rich foods (poultry, fish, peanuts, whole grains) supply a building block for NAD+ synthesis.
• Weight management: Excess adiposity is linked to lower NAD+ activity in some studies, making healthy weight maintenance relevant to NAD+ metabolism.
• Circadian health: Keeping consistent light exposure, meal timing, and sleep-wake cycles supports the body's natural NAD+ rhythms.